Coto-Segura Pablo, Santos-Juanes Jorge, Gómez Juan, Alvarez Victoria, Díaz Marta, Alonso Belén, Corao Ana I, Coto Eliecer
Dermatología II, Hospital Universitario Central Asturias (HUCA), Oviedo, Spain.
Genet Test Mol Biomarkers. 2012 Jun;16(6):621-3. doi: 10.1089/gtmb.2011.0266. Epub 2011 Dec 22.
Mitochondrial dysfunction could contribute to the pathogenesis of psoriasis (Ps) and Ps-arthritis (PsA). Several common mtDNA polymorphisms/haplogroups have been linked to differences in the production of reactive oxygen species and mitochondrial oxidative damage. To test the hypothesis of an association between mtDNA variants and Ps/PsA, we studied the single-nucleotide polymorphisms that define the common European haplogroups in a total of 325 patients and 300 controls from Spain. No allele/haplogroup was significantly associated with the risk for Ps. However, haplogroup J was significantly less frequent among patients with PsA, suggesting a protective effect in our population (p=0.04; odds ratio=0.39). We concluded that mtDNA may have a role in Ps and PsA.
线粒体功能障碍可能与银屑病（Ps）和银屑病关节炎（PsA）的发病机制有关。几种常见的线粒体DNA多态性/单倍群与活性氧产生和线粒体氧化损伤的差异有关。为了验证线粒体DNA变异与Ps/PsA之间存在关联的假设，我们研究了定义常见欧洲单倍群的单核苷酸多态性，共纳入了来自西班牙的325例患者和300例对照。没有等位基因/单倍群与Ps风险显著相关。然而，PsA患者中单倍群J的频率显著较低，表明在我们的人群中有保护作用（p=0.04；优势比=0.39）。我们得出结论，线粒体DNA可能在Ps和PsA中起作用。
