Department of Medical Laboratory, Faculty of Allied Health, Kuwait University, Sulaibekhat, Kuwait,
Department of Molecular Medicine, College of Medical and Medicine Sciences, Arabian Gulf University, Manama, Bahrain.
Med Princ Pract. 2021;30(1):62-68. doi: 10.1159/000509937. Epub 2020 Jul 6.
Published data show a clear link between psoriasis (Ps) and the increasing prevalence of comorbid conditions, such as diabetes mellitus type 2 (DM2). The role of the mitochondrial genomic haplogroup in the potential coexistence of Ps and DM2 comorbidity is the subject of this study.
Ninety-eight Kuwaiti individuals were recruited in 4 cohorts (20 healthy controls, 15 with DM2, 34 with Ps, and 29 with Ps and diabetes mellitus). An Ion Torrent S5XL was used to sequence mitochondrial DNA (mtDNA). χ2 test was used to assess differences in the distribution of each haplogroup between cases and controls (p < 0.05). The Bonferroni correction was applied (p < 0.004). The mtDNA haplogroups were analyzed by HaploGrep.
Haplogroups R0, U, J, T, N, L3, M, H, X, HV, R, and K were detected in the studied population. Haplogroup M had a high risk for Ps (odds ratio (OR) 4.0, p = 0.003). Haplogroup R0 and J had decreased the risk of DM2 (OR 0.28, p = 0.007).
Our results indicated that mtDNA haplogroups have a potential contribution to the pathogenesis of Ps and DM2 comorbidity. We show for the first time that the comorbidity of diabetes in Ps may be related to mitochondrial dysfunction.
已有数据表明，银屑病（Ps）与 2 型糖尿病（DM2）等合并症的患病率不断增加之间存在明显关联。本研究旨在探讨线粒体基因组单倍群在 Ps 与 DM2 合并症潜在共存中的作用。
在 4 个队列中招募了 98 名科威特个体（20 名健康对照者、15 名 DM2 患者、34 名 Ps 患者和 29 名 Ps 合并糖尿病患者）。使用 Ion Torrent S5XL 对线粒体 DNA（mtDNA）进行测序。使用 χ2 检验评估病例组和对照组之间每个单倍群分布的差异（p<0.05）。应用 Bonferroni 校正（p<0.004）。通过 HaploGrep 分析 mtDNA 单倍群。
在所研究的人群中检测到了单倍群 R0、U、J、T、N、L3、M、H、X、HV、R 和 K。单倍群 M 患 Ps 的风险较高（优势比（OR）4.0，p=0.003）。单倍群 R0 和 J 降低了患 DM2 的风险（OR 0.28，p=0.007）。
我们的研究结果表明，mtDNA 单倍群可能对 Ps 和 DM2 合并症的发病机制有一定的影响。我们首次表明，Ps 合并糖尿病可能与线粒体功能障碍有关。
