Zhejiang University, State Key Lab of Modern Optical Instrumentation, 38 Zheda Rd., Hangzhou 310027, China.
J Biomed Opt. 2011 Dec;16(12):126008. doi: 10.1117/1.3662450.
A high speed swept source optical coherence tomography (SS-OCT) system capable of full-range imaging is presented. Wave-number carrier frequency is introduced into the spectral interference signal by a transmissive dispersive optical delay line (TDODL). High carrier frequency in the spectral interference signal corresponding to an equivalent distance-shift is exploited to obtain full-range OCT imaging. Theoretical development is conducted with the instantaneous coherence function introduced for a complete description of a spectral interference signal. Performance advantage of the TDODL-based method over the conventional approach where only one side (positive or negative path length difference) is used for imaging to avoid overlaying mirror artifacts is confirmed by the measured envelopes of spectral interference signal. Feasibility of the proposed method for full-range imaging is validated in a custom-built SS-OCT system by in vivo imaging of a biological sample.
提出了一种能够进行全范围成像的高速扫频光相干断层扫描（SS-OCT）系统。通过透射色散光延迟线（TDODL）将波数载波频率引入光谱干涉信号。利用光谱干涉信号中对应等效距离移动的高载波频率来获得全范围 OCT 成像。通过引入瞬时相干函数对光谱干涉信号进行完整描述，进行了理论开发。所提出的方法通过测量光谱干涉信号的包络，证实了相对于传统方法的性能优势，传统方法仅使用一侧（正或负路径长度差）进行成像以避免重叠镜伪影。通过对生物样本的体内成像，在定制的 SS-OCT 系统中验证了该方法进行全范围成像的可行性。
