罗马尼亚东北部地区宫颈病变妇女与无宫颈病变妇女的 HPV 感染率及型别分布。
HPV prevalence and type distribution in women with or without cervical lesions in the Northeast region of Romania.
机构信息
Microbiology Department, "Grigore T. Popa" University of Medicine and Pharmacy, Universitatii Str, NO 15, Iaşi 700115, Romania.
出版信息
Virol J. 2011 Dec 22;8:558. doi: 10.1186/1743-422X-8-558.
BACKGROUND
Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical cancer in Europe, the prevalence of HPV has not been evaluated. We report the first data on HPV prevalence and type distribution in Northeast Romania.
METHODS
HPV prevalence and genotype distribution was investigated in 514 consecutively women with or without cervical lesions in Northeast Romania. Genotyping was performed with Linear Array Genotyping/Roche kit.
RESULTS
In our study group, 192/514 (37.4%) patients were positive for HPV (infected with single and with multiple HPV types). Most frequent types were: 16 (10.5%), 53 (5.44%), 51 (5.05%), 52 (4.08%) 18 (2.91%) and 31 (2.73%).
CONCLUSIONS
Infection with high risk types of HPV is common in Northeast Romania. Enhanced and systematic screening for cervical cancer is needed. Our results call for the implementation of a National HPV vaccine program in Romania.
背景
宫颈癌是全球重大公共卫生问题。罗马尼亚是欧洲宫颈癌发病率最高的国家，但其 HPV 流行率尚未得到评估。我们报告了罗马尼亚东北部 HPV 流行率和型别分布的首批数据。
方法
本研究对罗马尼亚东北部 514 例有或无宫颈病变的连续女性进行了 HPV 流行率和基因型分布调查。采用 LinearArray Genotyping/Roche 试剂盒进行基因分型。
结果
在我们的研究组中，192/514（37.4%）例患者 HPV 阳性（感染单一和多种 HPV 类型）。最常见的类型是：16（10.5%）、53（5.44%）、51（5.05%）、52（4.08%）、18（2.91%）和 31（2.73%）。
结论
高危型 HPV 感染在罗马尼亚东北部很常见。需要加强和系统的宫颈癌筛查。我们的研究结果呼吁在罗马尼亚实施国家 HPV 疫苗接种计划。
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