Department of Obstetrics and Gynecology, Hangzhou Women's Hospital, Hangzhou, China.
Department of Clinical Laboratory, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Sci Rep. 2021 Aug 16;11(1):16538. doi: 10.1038/s41598-021-96131-y.
This paper aimed to investigate the characteristics of female HPV infection in the Shangcheng District, Hangzhou city, China. The retrospective study was designed to analyze the HPV prevalence rate of 22,382 women receiving physical examinations from 2016 to 2020 in the Shangcheng District of Hangzhou city in China. A commercial kit was designed to detect the HPV genotypes. Trends were examined for age-specific groups (≤ 30 years, 31-44 years, 45-54 years, 55-64 years, ≥ 65 years). A receiver operating characteristic (ROC) analysis was used to assess the correlation of age classification in high risk HPV (HR-HPV) infection. 22.41% (5015/22,382) of samples were HPV positive, 91.28% (4578/5015) of HPV positive women were infected by HR-HPV. The most prevalent HR-HPV genotypes were 16, 52, 18, 58, 56, and 51. The trend of HPV prevalence showed the significant differences in age-specific groups (χ = 164.70, P < 0.001). Moreover, the areas under ROC curve (AUC) was 0.712 in 55-64 years group which showed a strong contribution of age classification for HR-HPV infection. This study provided baseline data on the prevalence characteristics of HPV infection and the critical age group of HR-HPV prevalence rate was 55-64 y among the samples receiving physical examinations.
本研究旨在探讨中国杭州市上城区女性 HPV 感染的特征。采用回顾性研究设计，分析了 2016 年至 2020 年期间在中国杭州市上城区接受体检的 22382 名女性的 HPV 流行率。采用商业试剂盒检测 HPV 基因型。按年龄组（≤30 岁、31-44 岁、45-54 岁、55-64 岁、≥65 岁）进行年龄特异性分析。采用受试者工作特征（ROC）分析评估年龄分类与高危型 HPV（HR-HPV）感染的相关性。22382 例样本中，HPV 阳性率为 22.41%（5015/22382），HPV 阳性女性中，91.28%（4578/5015）感染 HR-HPV。最常见的 HR-HPV 基因型为 16、52、18、58、56 和 51。HPV 流行趋势在年龄组之间存在显著差异（χ²=164.70，P<0.001）。此外，55-64 岁组 ROC 曲线下面积（AUC）为 0.712，表明年龄分类对 HR-HPV 感染有较强的贡献。本研究提供了 HPV 感染流行特征的基线数据，在接受体检的样本中，HR-HPV 流行率的关键年龄组为 55-64 岁。
