Center for Research in Reproduction, Division of Endocrinology, University of Virginia, Charlottesville, Virginia, USA.
Fertil Steril. 2012 Jan;97(1):18-22. doi: 10.1016/j.fertnstert.2011.11.036.
PRO--A large majority of women with PCOS have insulin resistance, compensatory hyperinsulinemia with consequent reproductive and metabolic abnormalities. Metformin has been shown to be effective therapy and could be used more widely in obese adolescents with hyperandrogenemia, a forerunner of PCOS. CON--The severity of insulin resistance is highly variable in women with PCOS and may not be clinically relevant in milder phenotypes. Treatment should be directed at specific metabolic or reproductive problems and insulin sensitizing drugs are not always the optimum therapy.
PRO-大多数患有 PCOS 的女性都存在胰岛素抵抗，代偿性高胰岛素血症导致生殖和代谢异常。二甲双胍已被证明是一种有效的治疗方法，并且可以在患有高雄激素血症的肥胖青少年中更广泛地使用，高雄激素血症是 PCOS 的前兆。CON-患有 PCOS 的女性的胰岛素抵抗严重程度差异很大，在较轻的表型中可能没有临床意义。治疗应针对特定的代谢或生殖问题，胰岛素增敏药物并不总是最佳治疗方法。
