Gusain Neelam, Anjankar Ashish P, Ambad Ranjit S, Jha Roshan K, Jha Rakesh
Department of Biochemistry, Jawaharlal Nehru Medical College, DMIHER (DU), Sawangi (M), Wardha, Maharashtra, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S130-S132. doi: 10.4103/jpbs.jpbs_1995_24. Epub 2025 Feb 15.
One of the biggest health issues facing women in their childbearing years worldwide is polycystic ovarian syndrome, or PCOS. PCOS is a prevalent endocrine condition with well-known negative effects on metabolism, reproduction, and cardiovascular health that contribute to substantial morbidity. There are still many unanswered questions regarding the precise mechanisms by which PCOS arises, and research into the disorder's nature is ongoing. This study aims to investigate this uncharted horizon of PCOS by analyzing association between serum Caspase-1, IL-10, and biochemical indices relative to insulin resistance (HOMA-IR), hyperandrogenism (FAI), dyslipidemia, and oxidative stress in our female population. It expands on the significance of inflammation and insulin resistance, together with dyslipidemia in the advancement and signs and symptoms of PCOS. The work's preface highlights the goal of advancing medical science's ability to treat patients with illnesses and makes the case that interdisciplinary cooperation between gynecology, endocrinology, and biochemistry improves patient care. Our objective is to identify potential strategies to lessen the effects of PCOS in order to enhance the results of its diagnostic, therapeutic, and preventative measures for the millions of women who are affected.
全球育龄女性面临的最大健康问题之一是多囊卵巢综合征(PCOS)。PCOS是一种常见的内分泌疾病,对代谢、生殖和心血管健康有众所周知的负面影响,会导致大量发病情况。关于PCOS发病的确切机制仍有许多未解答的问题,对该疾病本质的研究仍在进行中。本研究旨在通过分析血清半胱天冬酶-1、白细胞介素-10与我们女性人群中与胰岛素抵抗(HOMA-IR)、高雄激素血症(FAI)、血脂异常和氧化应激相关的生化指标之间的关联,来探究PCOS这一未知领域。它扩展了炎症和胰岛素抵抗以及血脂异常在PCOS进展和体征症状方面的重要性。该研究的前言强调了提高医学治疗疾病患者能力的目标,并论证了妇科、内分泌学和生物化学之间的跨学科合作可改善患者护理。我们的目标是确定减轻PCOS影响的潜在策略,以便改善数百万受影响女性的诊断、治疗和预防措施的效果。