Aging Research Center, Karolinska Institutet, Stockholm, Sweden.
Neurobiol Aging. 2012 Oct;33(10):2282-90. doi: 10.1016/j.neurobiolaging.2011.11.019. Epub 2011 Dec 20.
Vitamin E includes 8 natural compounds (4 tocopherols, 4 tocotrienols) with potential neuroprotective activity. α-Tocopherol has mainly been investigated in relation to cognitive impairment. We examined the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopherylquinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopherylquinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people. Compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD.
维生素 E 包括 8 种具有潜在神经保护活性的天然化合物（4 种生育酚、4 种生育三烯酚）。α-生育酚主要与认知障碍有关。我们研究了所有血浆维生素 E 形式和维生素 E 损伤标志物（α-生育酚醌、5-硝基-γ-生育酚）与轻度认知障碍（MCI）和阿尔茨海默病（AD）的关系。在 AddNeuroMed-Project 中，我们评估了 168 例 AD 病例、166 例 MCI 和 187 例认知正常（CN）人群的血浆生育酚、生育三烯酚、α-生育酚醌和 5-硝基-γ-生育酚。与认知正常的受试者相比，AD 和 MCI 的总生育酚、总生育三烯酚和总维生素 E 水平较低。在多变量多分类逻辑回归分析中，MCI 和 AD 病例处于总生育酚和总维生素 E 最高三分位的可能性分别降低了 85%，处于总生育三烯酚最低三分位的可能性分别降低了 92%和 94%。此外，这两种疾病都与维生素 E 损伤的增加有关。血浆生育酚和生育三烯酚水平较低与 MCI 和 AD 的发病风险增加有关。
