Geriatric Unit, Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milan, Italy.
Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, Perugia, Italy.
Aging Clin Exp Res. 2020 Mar;32(3):459-464. doi: 10.1007/s40520-019-01209-3. Epub 2019 May 3.
Vitamin E represents a potent antioxidant and anti-inflammatory system, playing a role in Alzheimer's disease (AD). Different plasma concentrations of the forms of vitamin E are observed in AD compared to cognitively healthy subjects.
Since these modifications may modulate the markers of oxidative stress and cellular aging, we aim to explore the relationship between vitamin E forms and leukocyte telomere length (LTL) in AD.
53 AD subjects and 40 cognitively healthy controls (CTs) were enrolled. The vitamin E forms (α-, β-, γ- and δ-tocopherol, α-, β-, γ- and δ-tocotrienol), the ratio of α-tocopherylquinone/α-tocopherol and 5-nitro-γ-tocopherol/γ-tocopherol (markers of oxidative/nitrosative damage) and LTL were measured.
Regression model was used to explore the associations of vitamin E forms and LTL with AD. The interaction of LTL in the association between vitamin E forms and AD was tested. AD subjects showed significantly lower concentrations of α-, β-, γ- and δ-tocopherol, α- and δ-tocotrienol, total tocopherols, total tocotrienols and total vitamin E compared to CTs. AD subjects showed higher values of nitrosative/oxidative damage. The adjusted analyses confirmed a significant relationship of AD with plasma concentrations of α- and β-tocopherols, δ-tocotrienol, total tocopherols, total tocotrienol, total vitamin E and oxidative/nitrosative damage. However, nitrosative damage was significantly associated with AD only in subjects with higher LTL and not in those expressing marked cellular aging.
Our study confirms the role of vitamin E in AD pathology and indicates that nitrosative damage influences the association with AD only in subjects characterized by longer LTL.
维生素 E 是一种有效的抗氧化剂和抗炎系统，在阿尔茨海默病（AD）中发挥作用。与认知健康的受试者相比，AD 患者的维生素 E 形式的血浆浓度不同。
由于这些变化可能会调节氧化应激和细胞衰老的标志物，我们旨在探索 AD 中维生素 E 形式与白细胞端粒长度（LTL）之间的关系。
纳入 53 名 AD 患者和 40 名认知健康对照者（CTs）。测量了维生素 E 形式（α-、β-、γ-和δ-生育酚、α-、β-、γ-和δ-生育三烯酚）、α-生育酚醌/α-生育酚的比值和 5-硝基-γ-生育酚/γ-生育酚（氧化/硝化损伤的标志物）以及 LTL。
使用回归模型来探讨维生素 E 形式与 AD 之间的关系。测试了 LTL 在维生素 E 形式与 AD 之间的关系中的交互作用。与 CTs 相比，AD 患者的α-、β-、γ-和δ-生育酚、α-和δ-生育三烯酚、总生育酚、总生育三烯酚和总维生素 E 浓度显著降低。AD 患者的硝化/氧化损伤值较高。调整后的分析证实 AD 与血浆浓度的α-和β-生育酚、δ-生育三烯酚、总生育酚、总生育三烯酚、总维生素 E 以及氧化/硝化损伤显著相关。然而，只有在 LTL 较高的受试者中，硝化损伤与 AD 显著相关，而在表现出明显细胞衰老的受试者中则不然。
我们的研究证实了维生素 E 在 AD 病理中的作用，并表明硝化损伤仅在 LTL 较长的受试者中影响与 AD 的关联。
