Pancreatoduodenectomy is an effective operative procedure for benign large tumors and cancers of the pancreas and periampullary sites and extensive trauma to these areas. 2. Pancreatoduodenectomy may be performed in two stages: total excision of pancreas, subtotal excision, and pyloric exclusion procedures. 3. Carcinoma of the proximal pancreas is a serious medicosurgical problem, and radical pancreatoduodenectomy is the most effective form of therapy. 4. Pancreatoduodenectomy is a major operative procedure with serious intraoperative and postoperative complications that are directly related to the experience of the surgeon.