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分娩时的局部与静脉镇痛。

Regional versus IV analgesics in labor.

机构信息

Faculty of Pharmacy, MSA University , 6th October City, Egypt.

出版信息

Minerva Med. 2011 Oct;102(5):353-61.

Abstract

AIM

The aim of this study was to compare combined spinal epidural (CSE), epidural (E) and IV pethidine analgesia and their effects on the mother, fetus, newborn and the labor course.

METHODS

This is a prospective parallel single blind study, where 60 women in active labor were recruited and were allocated to five subgroups to receive analgesia by different routes. The mother and the fetus were assessed. The results were recorded and compared using Visual Analogue Scale (VAS) and modified Bromage scale for motor block, in addition to other clinical findings.

RESULT

The duration of first stage of labor was significantly longer in the E group, compared with the CSE and IV pethidine groups. When the pain control achieved by CSE bupivacaine and lidocaine was compared with the corresponding epidural, it was found that the first technique achieved better pain control. Women who received pethidine had higher incidence of nausea and vomiting compared to those received CSE or E analgesia. There was no significant difference between the five groups with respect to other side effects.

CONCLUSION

Regional analgesia especially CSE using bupivacaine or lidocaine is a safe effective method for analgesia in labor with relative better efficacy of bupivacaine.

摘要

目的

本研究旨在比较脊髓-硬膜外联合麻醉(CSE)、硬膜外麻醉(E)和静脉哌替啶镇痛及其对母亲、胎儿、新生儿和分娩过程的影响。

方法

这是一项前瞻性平行单盲研究,纳入了 60 名活跃期产妇,并将其分配到五个亚组,通过不同途径接受镇痛。评估母亲和胎儿。使用视觉模拟评分(VAS)和改良 Bromage 量表评估运动阻滞程度,并记录和比较其他临床发现。

结果

与 CSE 和 IV 哌替啶组相比,E 组第一产程明显延长。当比较 CSE 布比卡因和利多卡因与相应的硬膜外镇痛时,发现前者能更好地控制疼痛。与接受 CSE 或 E 镇痛的产妇相比,接受哌替啶的产妇恶心和呕吐的发生率更高。五组之间在其他副作用方面无显著差异。

结论

区域镇痛,尤其是使用布比卡因或利多卡因的 CSE,是分娩镇痛的一种安全有效的方法,其效果相对更好。

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