Church A C, Feller D
Pharmacol Biochem Behav. 1979 Mar;10(3):335-8. doi: 10.1016/0091-3057(79)90193-x.
Two mouse strains (C57BL/6By and BALB/cByJ) were found to differ widely in their sleep-time response to ethanol (3 g/kg), but showed no difference in their hypothermic response to the same ethanol dose. Comparison of brain cyclic nucleotide levels in the two strains revealed a strain difference in the brain cyclic AMP response to ethanol but no strain difference in the magnitude of the brain cyclic GMP change. Alcohol produced a significant drop in cerebellar cyclic GMP in both strains, and a decrease in cerebellar cyclic AMP in C57BL/6By mice. The cyclic AMP/cyclic GMP ratio increased following alcohol in the cerebellum of BALB/cByJ mice but not C57BL/6By mice. The results are discussed in terms of possible relationships between alcohol-induced changes in neurochemistry and behavior.
发现两种小鼠品系（C57BL/6By和BALB/cByJ）对乙醇（3克/千克）的睡眠时间反应差异很大，但对相同乙醇剂量的体温过低反应没有差异。对这两种品系的脑环核苷酸水平进行比较，发现它们对乙醇的脑环磷酸腺苷（cAMP）反应存在品系差异，但脑环磷酸鸟苷（cGMP）变化的幅度没有品系差异。酒精使两种品系的小脑cGMP显著下降，使C57BL/6By小鼠的小脑cAMP减少。BALB/cByJ小鼠小脑内酒精作用后cAMP/cGMP比值升高，而C57BL/6By小鼠则未升高。根据酒精诱导的神经化学变化与行为之间可能的关系对结果进行了讨论。
