一种用于固相合成肽醛的简单噁唑烷酮连接体。
A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes.
机构信息
Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210008, China.
出版信息
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1187-8. doi: 10.1016/j.bmcl.2011.11.081. Epub 2011 Nov 28.
PMID:22196121
Abstract
A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H(2)O (8:1:1) affords peptide aldehydes in high yield and purity.
摘要
一种非常简单且廉价的连接剂已被用于肽醛的固相合成。保护氨基酸醛通过二乙醇胺作为恶唑啉形成固定在 2-Cl(trt)树脂上。在经典的 Fmoc SPPS 之后，用 AcOH/DCM/H(2)O（8:1:1）处理树脂可得到高产率和高纯度的肽醛。
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