通过铜介导的有氧氧化脱氢环化和醛、胺的氧化合成恶唑。
Synthesis of oxazoles through copper-mediated aerobic oxidative dehydrogenative annulation and oxygenation of aldehydes and amines.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.
出版信息
Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11367-70. doi: 10.1002/anie.201206382. Epub 2012 Oct 9.
PMID:23047285
Abstract
A fragment-assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions. The transformation is highly efficient with the removal of six hydrogen atoms, including the cleavage of four C(sp(3))-H bonds.
摘要
一种片段组装策略被用于在温和条件下由芳基乙醛、胺和分子氧形成恶唑。该转化具有很高的效率，去除了六个氢原子，包括四个 C(sp(3))-H 键的断裂。
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