Department of Cytomorphology, University of Cagliari, Italy.
J Neuroimmunol. 2012 Feb 29;243(1-2):95-9. doi: 10.1016/j.jneuroim.2011.11.011. Epub 2011 Dec 22.
S100B is a Ca(2+)-binding protein expressed in the nervous system. Increased levels of S100B in the extracellular space have been detected in several neurological disorders. We investigated the response of human astrocytes to micromolar chronic concentrations of this protein measuring the expression of some costimulatory molecules, such as CD137, CD137-L, CD40, CD40-L, the chemokine RANTES and two growth factors FGF-2 and TGF-β2. Our findings suggest that high levels of S100B in the brain parenchyma may modulate the activation status of astrocytes decreasing their neuroprotective role and modifying their interaction with microglia and other inflammatory cells. This effect may contribute to evolution of some neurological disorders.
S100B 是神经系统中表达的一种 Ca(2+)-结合蛋白。在几种神经疾病中，已经检测到细胞外空间中 S100B 的水平升高。我们研究了人星形胶质细胞对这种蛋白质的毫摩尔慢性浓度的反应，测量了一些共刺激分子的表达，如 CD137、CD137-L、CD40、CD40-L、趋化因子 RANTES 和两种生长因子 FGF-2 和 TGF-β2。我们的研究结果表明，大脑实质中高水平的 S100B 可能调节星形胶质细胞的激活状态，降低其神经保护作用，并改变其与小胶质细胞和其他炎症细胞的相互作用。这种作用可能有助于一些神经疾病的发展。
