Balakrishnan Karthik, Majesky Mark, Perkins Jonathan A
University of Washington, Department of Otolaryngology/Head and Neck Surgery, Seattle, WA, USA.
Lymphat Res Biol. 2011;9(4):205-12. doi: 10.1089/lrb.2011.0018.
Lymphatic malformations and lymphatic-derived tumors commonly involve the head and neck, where they may be associated with bony abnormalities and other systemic symptoms. The reasons for the association between these disorders and local skeletal changes are largely unknown, but such changes may cause significant disease-related morbidity. Ongoing work in molecular and developmental biology is beginning to uncover potential reasons for the bony abnormalities found in head and neck lymphatic disease; this article summarizes current knowledge on possible mechanisms underlying this association.
淋巴管畸形和源自淋巴管的肿瘤通常累及头颈部，在这些部位它们可能与骨骼异常及其他全身症状相关。这些疾病与局部骨骼改变之间存在关联的原因大多尚不清楚，但此类改变可能导致显著的疾病相关发病率。分子生物学和发育生物学领域正在进行的研究开始揭示头颈部淋巴疾病中骨骼异常的潜在原因；本文总结了关于这种关联潜在机制的现有知识。
