North-West University, Faculty of Health Sciences, Unit for Drug Research and Development, Potchefstroom campus, Potchefstroom, 2520, South Africa.
Expert Opin Drug Deliv. 2012 Feb;9(2):219-30. doi: 10.1517/17425247.2012.647907. Epub 2011 Dec 23.
There is a growing need for the development of pharmaceutical excipients that could improve product performance and overcome the shortcomings of new drug moieties, such as their poor solubility and membrane permeability, as well as to aid with modern manufacturing processes.
Different types of functional excipients are discussed in this paper, in terms of their roles in modern dosage forms to optimize drug delivery and manufacturability. Functions of specialized excipients that are covered in this article include the enhancement of drug membrane permeability, the improvement of drug solubility and stability, the regulation of drug release in response to feedback mechanisms and assistance with the production of dosage forms.
Modern drug delivery systems rely on sophisticated excipients with multiple functions to improve overall product performance. The excipient market is expected to grow substantially with emerging trends in the development of these advanced drug delivery systems.
对于能够改善产品性能并克服新药部分的缺点（如溶解度和膜透过性差）的药物辅料的开发需求日益增长，同时也需要满足现代制造工艺的要求。
本文讨论了不同类型的功能性辅料，就其在现代剂型中的作用而言，旨在优化药物传递和可制造性。本文涵盖的特殊辅料的功能包括增强药物的膜透过性、提高药物的溶解度和稳定性、根据反馈机制调节药物释放以及帮助剂型生产。
现代药物输送系统依赖于具有多种功能的复杂辅料来提高整体产品性能。预计随着这些先进药物输送系统的发展趋势的出现，辅料市场将大幅增长。
