Virtua Neuroscience, Virtua Health System, Virtua Medical Group, Voorhees, NJ 08043, USA.
Epilepsy Behav. 2012 Jan;23(1):79-80. doi: 10.1016/j.yebeh.2011.10.023. Epub 2011 Dec 23.
Treatment of refractory idiopathic primary generalized epilepsy can be very challenging, with limited drug options, especially in young women of childbearing age. Here we describe the cases of two young women with refractory idiopathic primary generalized epilepsy refractory to multiple antiepileptic drugs in monotherapy or combination before achieving a long-term remission with adjunctive lacosamide (LCS) treatment. Larger, randomized prospective studies are necessary to establish the effectiveness of lacosamide in these patients.
治疗耐药性特发性全面性癫痫非常具有挑战性，可供选择的药物有限，特别是在有生育能力的年轻女性中。在此，我们描述了两例年轻女性的病例，她们在接受多种抗癫痫药物单药或联合治疗后仍未缓解，随后接受了附加左乙拉西坦（LCS）治疗，最终实现了长期缓解。需要更大规模、前瞻性随机研究来确定左乙拉西坦在这些患者中的有效性。
