拉科酰胺用于临床实践中起源于非局灶性的难治性全面强直阵挛发作：一项临床及视频脑电图研究。
Lacosamide for refractory generalized tonic-clonic seizures of non-focal origin in clinical practice: A clinical and VEEG study.
作者信息
Abarrategui Belén, García-García María Eugenia, Toledano Rafael, Parejo-Carbonell Beatriz, Gil-Nagel Antonio, García-Morales Irene
机构信息
Epilepsy Unit, Department of Neurology, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, Spain.
Epilepsy Unit, Department of Neurology, Hospital Ruber Internacional, La Masó 38, Mirasierra, 28034 Madrid, Spain.
出版信息
Epilepsy Behav Case Rep. 2017 Aug 24;8:63-65. doi: 10.1016/j.ebcr.2017.08.001. eCollection 2017.
Abstract
•7 of 9 patients with GGE reduced ≥ 50% their tonic-clonic seizure frequency on LCM.•All 7 patients remained seizure free for > 1 year, and 2 of them for > 5 years.•In 2 of the 9 patients, both with Juvenile Absence Epilepsy, absences aggravated.•One aggravation consisted on a myoclonia and absence status, in a patient with no history of myoclonia.•VEEG paralleled clinical improvement but didn't change in a case of absence worsening.
摘要
•9例全面性癫痫伴中央颞区棘波（GGE）患者中有7例在服用拉考沙胺（LCM）后强直阵挛发作频率降低≥50%。
•所有7例患者均有>1年无癫痫发作，其中2例>5年无癫痫发作。
•9例患者中有2例均为青少年失神癫痫，失神发作加重。
•1例加重表现为肌阵挛和失神持续状态，该患者既往无肌阵挛病史。
•视频脑电图（VEEG）与临床改善情况平行，但在1例失神发作恶化的病例中无变化。
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