Abarrategui Belén, García-García María Eugenia, Toledano Rafael, Parejo-Carbonell Beatriz, Gil-Nagel Antonio, García-Morales Irene
Epilepsy Unit, Department of Neurology, Hospital Clínico San Carlos, Profesor Martín Lagos s/n, 28040 Madrid, Spain.
Epilepsy Unit, Department of Neurology, Hospital Ruber Internacional, La Masó 38, Mirasierra, 28034 Madrid, Spain.
Epilepsy Behav Case Rep. 2017 Aug 24;8:63-65. doi: 10.1016/j.ebcr.2017.08.001. eCollection 2017.
•7 of 9 patients with GGE reduced ≥ 50% their tonic-clonic seizure frequency on LCM.•All 7 patients remained seizure free for > 1 year, and 2 of them for > 5 years.•In 2 of the 9 patients, both with Juvenile Absence Epilepsy, absences aggravated.•One aggravation consisted on a myoclonia and absence status, in a patient with no history of myoclonia.•VEEG paralleled clinical improvement but didn't change in a case of absence worsening.
•9例全面性癫痫伴中央颞区棘波（GGE）患者中有7例在服用拉考沙胺（LCM）后强直阵挛发作频率降低≥50%。
•所有7例患者均有>1年无癫痫发作，其中2例>5年无癫痫发作。
•9例患者中有2例均为青少年失神癫痫，失神发作加重。
•1例加重表现为肌阵挛和失神持续状态，该患者既往无肌阵挛病史。
•视频脑电图（VEEG）与临床改善情况平行，但在1例失神发作恶化的病例中无变化。
