School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China; School of Materials and Chemical Engineering, Henan Institute of Technology, Zhengzhou 450007, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China.
Int J Biol Macromol. 2015 Feb;73:1-8. doi: 10.1016/j.ijbiomac.2014.10.066. Epub 2014 Nov 20.
Compartmentalized biomineralized alginate beads ranging from the micro to the visible scales with thermal- and pH-responsive drug delivery properties have been prepared via a one-step method in the present paper. Hollow multilayer microcapsules made of aliphatic poly(urethane-amine) (PUA) and sodium poly(styrenesulfonate) (PSS) serve as drug container to slow down the drug release. The results indicate that internal hollow multilayer microcapsules could hinder the permeation of the encapsulated Vitamin B2 (VB2) and retard the initial burst release of VB2. In addition, the drug release of compartmentalized biomineralized alginate beads exhibit distinguished pH- and thermal-dependent property due to pH-responsive alginate and the thermal-responsive aliphatic PUA. The drug release decreases when decreasing the pH value because the compact construction of alginate and biomineralized layer could prevent VB2 release from the beads. Moreover, the drug release is higher at 55 °C than that at 37 °C for the sake of the shrinkage of aliphatic PUA above its lower critical solution temperature (LCST). The results demonstrate that the compartmentalized biomineralized alginate beads show great potential as smart materials for controllable drug delivery.
本文通过一步法制备了具有热响应和 pH 响应药物传递性能的分腔生物矿化海藻酸钠微球，其尺寸范围从微观到可见尺度。以脂肪族聚（聚氨酯-胺）（PUA）和聚（苯乙烯磺酸钠）（PSS）为壁材的中空多层微胶囊作为药物容器，以减缓药物释放。结果表明，内部中空多层微胶囊可以阻碍包封的维生素 B2（VB2）的渗透，并延缓 VB2 的初始突释。此外，由于 pH 响应的海藻酸钠和热响应的脂肪族 PUA，分腔生物矿化海藻酸钠微球的药物释放表现出明显的 pH 和温度依赖性。当降低 pH 值时，药物释放减少，因为海藻酸钠和生物矿化层的紧密结构可以防止 VB2 从微球中释放出来。此外，由于脂肪族 PUA 在上临界溶液温度（LCST）以上收缩，55°C 时的药物释放高于 37°C。结果表明，分腔生物矿化海藻酸钠微球作为可控药物传递的智能材料具有很大的潜力。
