与炎症性肠病青少年和成年患者硫唑嘌呤不依从相关的因素。
Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease.
机构信息
Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary's University, London, UK.
出版信息
J Pediatr Gastroenterol Nutr. 2012 May;54(5):685-9. doi: 10.1097/MPG.0b013e3182475e71.
OBJECTIVES
We hypothesised that nonadherence to thiopurines is more common in adolescents than in adults with inflammatory bowel disease.
METHODS
We sought factors associated with thiopurine nonadherence defined by thiopurine metabolite levels.
RESULTS
Multivariate logistic regression confirmed that adolescents (odds ratio [OR] 4.6 [95% confidence interval [CI] 1.9-11.5]; P < 0.01) compared with adults, patients with Crohn disease (OR 3.3 [CI 1.1-10.5] P = 0.04) compared with ulcerative colitis, and patients living in more socially deprived areas (OR 1.03 [CI 1.0-1.1] P = 0.02) were more likely to be nonadherent to thiopurines.
CONCLUSIONS
Adolescents are more frequently nonadherent than adults: prospective studies are required to determine the reasons for nonadherence in adolescents.
目的
我们假设，与炎症性肠病的成年人相比，青少年对硫嘌呤的依从性更差。
方法
我们寻找与硫嘌呤代谢物水平定义的硫嘌呤不依从相关的因素。
结果
多变量逻辑回归证实，与成年人相比，青少年（比值比[OR]4.6[95%置信区间[CI]1.9-11.5]；P <0.01），克罗恩病患者（OR 3.3[CI 1.1-10.5]P = 0.04）与溃疡性结肠炎相比，以及生活在社会资源更匮乏地区的患者（OR 1.03[CI 1.0-1.1]P = 0.02）更有可能不依从硫嘌呤。
结论
青少年比成年人更频繁地不依从：需要前瞻性研究来确定青少年不依从的原因。
Zotero 插件