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[非致命烧伤后大鼠心脏中儿茶酚胺的代谢周转]

[Metabolic turnover of catecholamines in the heart of rats after nonfatal burns].

作者信息

Vujnov S, Savić J, Bacić F, Varagić V M

机构信息

Vojnomedicinska akademija, Institut za eksperimentalnu medicinu.

出版信息

Vojnosanit Pregl. 1990 May-Jun;47(3):163-6.

PMID:2219797
Abstract

The content and metabolic turnover of noradrenaline (NA) and adrenaline (A) have been studied in the hearts of rats subjected to nonlethal scalding. The results of the study have shown that in an early phase of the general reaction of the organism to thermal trauma it has come to the decreased NA content while in the later phase the NA content was in the limits of control values. The increased contents of Na and A in the murine hearts after monoamineoxidase inhibition and injection of L-DOPA indicated the preservation of the synthesis and overtaking of catecholamines by the heart muscle. The increase of the metabolic turnover and shortening of the time of the metabolic turnover of NA and A have pointed that the increased NA content in the hearts of the traumatized animals is the consequence of the increased requirements of these catecholamines by the heart muscle in the early posttraumatic phase.

摘要

对遭受非致命性烫伤的大鼠心脏中去甲肾上腺素(NA)和肾上腺素(A)的含量及代谢转换进行了研究。研究结果表明,在机体对热创伤的一般反应早期,NA含量降低,而在后期,NA含量处于对照值范围内。单胺氧化酶抑制和注射L-多巴后,小鼠心脏中Na和A含量增加,表明心肌中儿茶酚胺的合成得以保留且被心肌摄取。NA和A的代谢转换增加及代谢转换时间缩短表明,创伤动物心脏中NA含量增加是创伤后早期心肌对这些儿茶酚胺需求增加的结果。

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