Viktorov A P, Zasenko I I
Farmakol Toksikol. 1982 Nov-Dec;45(6):38-41.
Examination of the myocardium of 7-, 30-day and 3--5-month-old rats has shown that the content of noradrenaline and adrenaline increased with age. The sympatholytics, reserpine and ornid diminished more markedly the content of catecholamines in the myocardium of 7- and 30-day-old animals. Dopegyt produced a greater catecholamine-reducing effect in 3--5-month-old animals. It is inferred that in the early postnatal ontogenesis, the myocardial response to the sympatholytics is determined by age-associated features of adrenergic control and metabolism.
对7日龄、30日龄和3 - 5月龄大鼠的心肌检查表明,去甲肾上腺素和肾上腺素的含量随年龄增加。交感神经阻滞剂利血平和奥尼德更显著地降低了7日龄和30日龄动物心肌中儿茶酚胺的含量。多匹吉特对3 - 5月龄动物产生了更大的儿茶酚胺降低作用。据推测,在出生后的早期个体发育中,心肌对交感神经阻滞剂的反应由肾上腺素能控制和代谢的年龄相关特征决定。