California Clinical Trials Medical Group, Glendale, CA 91206, USA.
J Clin Psychopharmacol. 2012 Feb;32(1):61-4. doi: 10.1097/JCP.0b013e31823f3b5f.
The objective of this study was to explore the efficacy of combination therapy with citalopram plus omega-3 fatty acids versus citalopram plus placebo (olive oil) in the initial treatment of individuals with major depressive disorder (MDD). We hypothesized that combination therapy would lead not only to greater efficacy but also to a more rapid onset of therapeutic response.
Forty-two subjects participated in this 9-week randomized, masked, placebo-controlled study of combination therapy (two 1 g capsules containing a blend of 900 mg of eicosapentaenoic acid, 200 mg of and docosahexaenoic acid, and 100 mg of other omega-3 fatty acids twice daily plus citalopram) versus monotherapy (two 1 g capsules of olive oil per day plus citalopram) treatment of MDD.
The combination therapy demonstrated significantly greater improvement in Hamilton Depression Rating scale scores over time (F = 7.32; df 1,177; P = 0.008) beginning at week 4 (t = -2.48; df 177; P = 0.014).
Combination therapy was more effective than monotherapy in decreasing signs and symptoms of MDD during the 8 weeks of active treatment; however, combination therapy did not seem to enhance the speed of the initial antidepressant response. These findings suggest that there may be an advantage to combining omega-3 fatty acids with a selective serotonin uptake inhibitor in the initial treatment of individuals with MDD. A larger definitive study is warranted.
本研究旨在探讨西酞普兰联合欧米伽-3 脂肪酸与西酞普兰联合安慰剂（橄榄油）治疗首发重性抑郁障碍（MDD）的疗效。我们假设联合治疗不仅能提高疗效，而且能更快地开始治疗反应。
42 名受试者参加了这项为期 9 周的随机、双盲、安慰剂对照研究，接受联合治疗（每日两次服用 2 粒含 900mg 二十碳五烯酸、200mg 二十二碳六烯酸和 100mg 其他欧米伽-3 脂肪酸的混合胶囊，外加西酞普兰）或单药治疗（每日两次服用 2 粒橄榄油胶囊，外加西酞普兰）。
联合治疗在汉密尔顿抑郁量表评分上的改善随着时间的推移（F = 7.32；df 1,177；P = 0.008）明显优于单药治疗，从第 4 周开始（t = -2.48；df 177；P = 0.014）。
在 8 周的积极治疗期间，联合治疗比单药治疗更能有效减轻 MDD 的症状和体征；然而，联合治疗似乎并没有加快初始抗抑郁反应。这些发现表明，在 MDD 的初始治疗中，联合使用欧米伽-3 脂肪酸和选择性 5-羟色胺再摄取抑制剂可能具有优势。需要进行更大规模的确定性研究。
