Vennila K N, Sankaran M, Mohan P S, Velmurugan D
Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3376-7. doi: 10.1107/S1600536811048896. Epub 2011 Nov 19.
The title compound, C(32)H(23)ClN(2)O(4), has a quinoline, a chloro-phenyl and an acenaphthalene ring system attached to a central pyrrolidine ring, which has three stereogenic centers. Nevertheless, the compound crystallizes as a racemate with two mol-ecules of identical chirality in the asymmetric unit. They differ in the conformation of the five-membered pyrrolidine ring; in one molecule it has an envelope conformation, while in the other molecule it has a twisted conformation. In each molecule there is an intra-molecular O-H⋯O hydrogen bond making an S(6) ring motif. In the crystal, pairs of N-H⋯O hydrogen bonds produce inversion dimers with R(2) (2)(8) motifs. There are also C-H⋯O interactions present. The crystal structure contains voids (60 Å(3)) within which there is no evidence of solvent mol-ecules.
标题化合物C(32)H(23)ClN(2)O(4)具有一个喹啉环、一个氯苯基和一个萘嵌苯环系统连接到一个中心吡咯烷环上，该吡咯烷环有三个手性中心。然而，该化合物以对映体混合物形式结晶，在不对称单元中有两个具有相同手性的分子。它们在五元吡咯烷环的构象上有所不同；在一个分子中它具有信封式构象，而在另一个分子中它具有扭曲构象。在每个分子中存在一个分子内O-H⋯O氢键，形成一个S(6)环模式。在晶体中，成对的N-H⋯O氢键产生具有R(2) (2)(8)模式的反演二聚体。还存在C-H⋯O相互作用。晶体结构包含空隙（60 Å(3)），其中没有溶剂分子的迹象。
