Schreiber H, Keller F, Kinzl H P, Hunger H, Knöfler W, Rübling U, Merten W
Institut für Gerichtliche Medizin, Bezirkskrankenhaus Gera, DDR.
Z Exp Chir Transplant Kunstliche Organe. 1990;23(1):23-5.
The histologic estimation of the subcutaneous connective-tissue reaction at implants forms an important part of the biocompatibility test. The connective-tissue capsulae around titanium implants in man, guinea-pig, and Wistar-rat were analysed by a special test system because of the question concerning the transmission of results of animal experiments on the man. The subsidence process of the thickness of the connective-tissue capsule and of the cell count per measuring fields were represented in dependence on the time. The findings showed the fundamental similar course of wound healing in man, guinea-pig, and Wistar-rat by the influence of an implant.
植入物周围皮下结缔组织反应的组织学评估是生物相容性测试的重要组成部分。由于存在动物实验结果能否应用于人类的问题，因此采用一种特殊的测试系统对人类、豚鼠和Wistar大鼠体内钛植入物周围的结缔组织囊进行了分析。结缔组织囊厚度和每个测量区域细胞计数的沉降过程随时间变化而呈现。研究结果表明，植入物的影响使得人类、豚鼠和Wistar大鼠的伤口愈合过程基本相似。
