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[脂质体的抗炎作用]

[Anti-inflammatory effects of liposomes].

作者信息

Kreĭnes V M, Mel'nikova V M, Margolin Ia M, Mel'iantseva L P, Gladshteĭn A I, Andriasian B A

出版信息

Vestn Akad Med Nauk SSSR. 1990(6):44-7.

PMID:2220038
Abstract

Studies of antiexudative, antialterative, and antibacterial effects of lecithin-cholesterol liposomes suggest their possible use as antiinflammatory agents. It is shown that incubation of liposomes with opportunistic microorganisms is attended with a pronounced antibacterial effect, while subcutaneous injection of liposomes significantly reduces the soft tissue edema caused by administration of formalin, and prevents pronounced alteration in response to acetic acid solution. A conclusion is derived on the possibility to use the membranotropic properties of liposomal membranes to alleviate manifestations of inflammation.

摘要

对卵磷脂 - 胆固醇脂质体的抗渗出、抗病变及抗菌作用的研究表明,它们有可能用作抗炎剂。结果显示,脂质体与机会性微生物一起孵育会产生显著的抗菌效果,而皮下注射脂质体可显著减轻因注射福尔马林引起的软组织水肿,并防止对醋酸溶液产生明显的病变反应。由此得出结论,利用脂质体膜的膜亲和特性来减轻炎症表现是有可能的。

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