Stefanov A V, Pozharov V P, Miniaĭlenko T D, Bryginskiĭ S A, Seredenko M M, Lishko V K
Vestn Akad Med Nauk SSSR. 1990(6):47-51.
The antihypoxic and antioxidative effects of phosphatidyl choline liposomes have been studied in hypoxic hypoxia, pneumonia, and acute blood loss. It was demonstrated that the body tolerance of persisting hypoxia increased on liposome administration due to elimination of lactate-acidosis, inhibition of lipid peroxidation and higher rate of oxygen diffusion through the biological barriers. The antihypoxic properties of the vesicles are determined by their remedial effect on the key mechanisms responsible for the development of hypoxic organ damage.
已在低氧性缺氧、肺炎和急性失血模型中研究了磷脂酰胆碱脂质体的抗缺氧和抗氧化作用。结果表明，给予脂质体后，由于消除了乳酸酸中毒、抑制了脂质过氧化以及提高了氧气通过生物屏障的扩散速率，机体对持续性缺氧的耐受性增强。这些囊泡的抗缺氧特性取决于它们对导致缺氧性器官损伤发生的关键机制的修复作用。
