Department of Medicine/Nephrology, VA Palo Alto HCS, Palo Alto, California 94303, USA.
J Ren Nutr. 2012 Jan;22(1):203-6. doi: 10.1053/j.jrn.2011.10.011.
Protein-bound solutes that accumulate in plasma when the kidneys fail are poorly cleared by conventional dialysis. Means have been developed to reduce the levels of such solutes, either by modifying the dialysis procedure to increase their clearance or by limiting their production. A trial testing whether reducing bound solute levels clinically benefits dialysis patients is required to determine whether these measures should be adopted in routine clinical practice.
当肾脏衰竭时，蛋白质结合的溶质会在血浆中积累，传统的透析方法很难清除这些溶质。已经开发出一些方法来降低这些溶质的水平，要么通过修改透析程序来增加其清除率，要么通过限制其产生。需要进行一项临床试验，以确定降低结合溶质水平是否能使透析患者临床受益，从而确定这些措施是否应在常规临床实践中采用。
