He Wei, Hu Zuo-jun, Xu An-wu, Yin Heng-hui, Wang Jin-song, Ye Jie-lian, Wang Shen-ming
Department of Vascular Surgery, Sun Yat-sen University, Guangzhou, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Dec;31(12):2006-11.
To develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility.
The effects of electrospinning conditions on the microstructure and porosity of the resulting scaffolds were investigated for preparation of a small-caliber (4 mm) polyurethane vascular grafts with optimum microstructures and mechanical properties. The mechanical properties and biocompatibility of the prepared grafts were evaluated.
The polyurethane vascular grafts showed a three-dimensional reticular structure consisting of nanofibers, with an average porosity of (51.48∓4.47)% and tensile strength of 5.85 ∓ 0.62 MPa. The grafts provided a better long-term support than e-PTFE graft for endothelial cell growth and endothelialization.
The polyurethane vascular prosthesis possessed favorable microstructures, excellent mechanical properties and good biocompatibility for potential clinical application.
研发一种小口径血管移植物，并研究其形态、力学性能和生物相容性。
研究静电纺丝条件对所得支架微观结构和孔隙率的影响，以制备具有最佳微观结构和力学性能的小口径（4毫米）聚氨酯血管移植物。对制备的移植物的力学性能和生物相容性进行评估。
聚氨酯血管移植物呈现出由纳米纤维组成的三维网状结构，平均孔隙率为（51.48±4.47）%，拉伸强度为5.85±0.62兆帕。与e-PTFE移植物相比，该移植物为内皮细胞生长和内皮化提供了更好的长期支持。
聚氨酯血管假体具有良好的微观结构、优异的力学性能和良好的生物相容性，具有潜在的临床应用价值。
