Miyamoto K, Sugimoto T, Okada M, Maeda S
Department of Surgery, Division II, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Ann Thorac Cardiovasc Surg. 1999 Jun;5(3):174-81.
It has been suggested that a microporous structure enhances fast and complete endothelialization. For long-term patency, antithrombogenicity and microporous structure are very important factors. In this paper, we have developed a new technique to give a micro-porous structure to small-caliber vascular prosthesis produced by polyurethane which has favorable antithrombogenecity. A mixed solution (tetrahydrofuran: dimethylformamide = 1:1) containing 13 wt% of segmented polyurethane and a variable amount of calcium carbonate (mean particle size of 8 mm in diameter) was dip-coated on a glass mandril of 3 mm and 6 mm in diameter and placed into distilled water for 24 hours. After the glass mandrill was removed, this polyurethane tube was placed into 1 mmol hydrochloric acid for 1 hour, and a microporous polyurethane vascular prosthesis of 20 mm in length was completed. These prostheses of 3 mm and 6 mm in diameter were implanted into the femoral and the carotid arteries, and the abdominal aorta of the dogs, respectively. Patency was recognized by arteriography and Duplex scanning and the removed grafts were inspected macro- and microscopically. Greater hydraulic permeability of this graft was obtained with an increase in the quantity of calcium carbonate mixed with polyurethane. In elasticity, this graft was more similar to the canine jugular vein than the polytetrafluoroethylene graft. Patency was observed 8 weeks after implantation on the arteriogram, and neointima was observed microscopically on the smooth and lustrous lumen. The new polyurethane vascular prosthesis we developed might provide a potential prosthesis for small-caliber vascular reconstruction.
有人提出，微孔结构可促进快速且完全的内皮化。对于长期通畅性而言，抗血栓形成性和微孔结构是非常重要的因素。在本文中，我们开发了一种新技术，用于赋予由具有良好抗血栓形成性的聚氨酯制成的小口径血管假体微孔结构。将含有13 wt% 分段聚氨酯和可变数量碳酸钙（平均粒径为8毫米）的混合溶液（四氢呋喃：二甲基甲酰胺 = 1:1）浸涂在直径为3毫米和6毫米的玻璃芯轴上，并置于蒸馏水中24小时。去除玻璃芯轴后，将该聚氨酯管放入1毫摩尔盐酸中1小时，完成了长度为20毫米的微孔聚氨酯血管假体。将这些直径为3毫米和6毫米的假体分别植入犬的股动脉、颈动脉和腹主动脉。通过动脉造影和双功扫描确认通畅性，并对取出的移植物进行宏观和微观检查。随着与聚氨酯混合的碳酸钙量增加，该移植物获得了更高的水力渗透性。在弹性方面，该移植物比聚四氟乙烯移植物更类似于犬颈静脉。植入8周后在动脉造影上观察到通畅性，在光滑有光泽的管腔上微观观察到新生内膜。我们开发的新型聚氨酯血管假体可能为小口径血管重建提供一种潜在的假体。
