Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Surg Today. 2012 Jan;42(2):181-4. doi: 10.1007/s00595-011-0106-4. Epub 2011 Dec 27.
Dilated cardiomyopathy (DCM) is a heart muscle disease characterized by progressive heart failure, and is a leading cause of mortality and morbidity. Recently, cellular therapy for end-stage heart failure has been emerging. We herein report a 56-year-old male who received a transplant of autologous myoblast sheets manufactured in temperature-responsive culture dishes. His clinical condition improved markedly, leaving him without any arrhythmia and able to discontinue using a left ventricular assist system and avoid cardiac transplantation. These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future.
扩张型心肌病（DCM）是一种以进行性心力衰竭为特征的心肌疾病，是导致死亡率和发病率的主要原因。最近，用于终末期心力衰竭的细胞疗法正在出现。本文报告了一名 56 岁男性患者，他接受了在温度响应培养皿中制造的自体成肌细胞片的移植。他的临床状况明显改善，没有任何心律失常，并且能够停止使用左心室辅助系统并避免心脏移植。这些发现表明，使用成肌细胞片的细胞疗法是治疗终末期 DCM 患者的一种有前途的新策略。这种方法在不久的将来可能成为心脏移植的有效替代方法。
