Koehrer P, Creuzot-Garcher C, Bron Alain M
Department of Ophthalmology, University Hospital, Hôpital Général, 3, rue du Faubourg Raines, 21033, Dijon, France.
Int Ophthalmol. 2011 Dec;31(6):517-24. doi: 10.1007/s10792-011-9492-2. Epub 2011 Dec 27.
We report two recent cases of methanol intoxication in French patients living in Bali. These intoxications were secondary to the consumption of adulterated liquor. Both patients presented acute bilateral loss of vision a few days after methanol ingestion with no sign of recovery. The fundus showed bilateral optic atrophy that was well correlated with retinal nerve fibre layer thickness measured with spectral-domain optical coherence tomography and compatible with toxic optic neuropathy. In one of the patients, macular swelling in one eye was observed. Electroretinograms were normal contrasting with abolished visual evoked potentials. Methanol was isolated from a sample of the beverage with gas chromatography. Methanol intoxication may occur in Asia and therefore adequate information for tourists and the local population is required.
我们报告了两例近期居住在巴厘岛的法国患者甲醇中毒的病例。这些中毒事件是由饮用掺假酒品所致。两名患者在摄入甲醇几天后均出现急性双侧视力丧失，且无恢复迹象。眼底检查显示双侧视神经萎缩，这与通过光谱域光学相干断层扫描测量的视网膜神经纤维层厚度高度相关，符合中毒性视神经病变。其中一名患者一只眼睛出现黄斑水肿。视网膜电图正常，与之形成对比的是视觉诱发电位消失。通过气相色谱法从饮料样本中分离出了甲醇。甲醇中毒在亚洲可能会发生，因此需要为游客和当地居民提供充分的信息。
