Günay H, Beier C
Zentrum Zahn-, Mund- und Kieferheilkunde, Medizinische Hochschule Hannover.
ZWR. 1990 Jul;99(7):564-8.
In this study 137 patients (30 adolescence, 2-21 years, 107 adults, 22-68 years), which had been treated with Cyclosporine-A, between 17 to 2461 days after organ transplantation, were examinated by gingival status. The severity of gingival hyperplasia increases in both groups with mean transplantations period, independent of mean daily doses of CsA and Azathioprin and independent of mean plasma concentration. Adolescence and adults differ significantly, in relation of each severity group frequency. The adolescence group includes 66.7% of the cases with gingival enlargement of severity degree 3. In both groups increases the mean value of PGI-Index with the severity degree.
在本研究中，对137例患者（30例青少年，年龄2至21岁，107例成年人，年龄22至68岁）进行了牙龈状况检查，这些患者在器官移植后17至2461天接受了环孢素A治疗。两组患者的牙龈增生严重程度均随平均移植时间增加，与环孢素A和硫唑嘌呤的平均每日剂量无关，也与平均血浆浓度无关。青少年和成年人在各严重程度组频率方面存在显著差异。青少年组中严重程度为3级的牙龈肿大病例占66.7%。两组患者的牙龈指数（PGI-Index）平均值均随严重程度增加。
