微小 RNA 在神经胶质瘤发生和进展中的作用。
The role of microRNAs in glioma initiation and progression.
机构信息
University of Virginia, Department of Microbiology, Charlottesville, VA 22908, USA.
出版信息
Front Biosci (Landmark Ed). 2012 Jan 1;17(2):700-12. doi: 10.2741/3952.
Abstract
micoRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting the mRNAs of a large number of human genes. Gliomas are the most common and deadly primary human brain tumors and are thought to originate from transformed stem-like cells (GSCs). microRNAs are frequently deregulated in cancer and gliomas and their deregulation has been associated with various aspects of glioma pathobiology. The present review summarizes the published literature on the role of miRNAs in gliomas with a focus on their role in GSCs.
摘要
微小 RNA（miRNA）是一类通过靶向大量人类基因的 mRNA 来调节基因表达的小型非编码 RNA。神经胶质瘤是最常见和最致命的原发性人脑肿瘤，据认为起源于转化的干细胞样细胞（GSCs）。miRNA 在癌症和神经胶质瘤中经常失调，其失调与神经胶质瘤病理生物学的各个方面有关。本综述总结了 miRNA 在神经胶质瘤中的作用的已发表文献，重点介绍了它们在 GSCs 中的作用。
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Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.表皮生长因子受体表达鉴定了人多形性胶质母细胞瘤中具有功能和分子特征的肿瘤起始细胞，并对神经胶质瘤的发生起作用。
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MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance.miRNA-196 在胶质母细胞瘤中上调，但在间变性星形细胞瘤中没有上调，并且具有预后意义。
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miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells.miR-195、miR-455-3p 和 miR-10a(*) 参与胶质母细胞瘤细胞获得性替莫唑胺耐药。
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