微小 RNA 在神经胶质瘤发生和进展中的作用。
The role of microRNAs in glioma initiation and progression.
机构信息
University of Virginia, Department of Microbiology, Charlottesville, VA 22908, USA.
出版信息
Front Biosci (Landmark Ed). 2012 Jan 1;17(2):700-12. doi: 10.2741/3952.
Abstract
micoRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting the mRNAs of a large number of human genes. Gliomas are the most common and deadly primary human brain tumors and are thought to originate from transformed stem-like cells (GSCs). microRNAs are frequently deregulated in cancer and gliomas and their deregulation has been associated with various aspects of glioma pathobiology. The present review summarizes the published literature on the role of miRNAs in gliomas with a focus on their role in GSCs.
摘要
微小 RNA（miRNA）是一类通过靶向大量人类基因的 mRNA 来调节基因表达的小型非编码 RNA。神经胶质瘤是最常见和最致命的原发性人脑肿瘤，据认为起源于转化的干细胞样细胞（GSCs）。miRNA 在癌症和神经胶质瘤中经常失调，其失调与神经胶质瘤病理生物学的各个方面有关。本综述总结了 miRNA 在神经胶质瘤中的作用的已发表文献，重点介绍了它们在 GSCs 中的作用。
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