Department for Molecular Biomedical Research, Ghent University and VIB, B-9052 Ghent, Belgium.
Front Biosci (Landmark Ed). 2012 Jan 1;17(2):760-83. doi: 10.2741/3956.
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing. These isoforms fulfill pleiotropic functions according to their subcellular localization: modulating the turnover rate of membrane-bound cadherins, regulating the activation of small Rho GTPases in the cytoplasm, and modulating nuclear transcription. Over the last two decades, knowledge of p120ctn has grown remarkably, and this has been achieved in part by using different animal models. At least in frog and mammals, p120ctn is essential for normal development and homeostasis. Here we will discuss the effects of different p120ctn isoforms on cadherin turnover and on signaling in the cytoplasm and the nucleus. We will also elaborate on the structure and function of other members of the p120ctn subfamily: ARVCF, p0071 and delta-catenin. Finally, we will overview the respective roles of p120ctn family members in pathological processes, and particularly in cancer as p120ctn is frequently.
p120 连环蛋白（p120ctn）是钙黏着蛋白连环蛋白复合物的一个组成部分，是首次在 Armadillo 家族的一个非常有趣的亚家族中被鉴定出来的成员。几种 p120ctn 异构体通过选择性剪接产生。这些异构体根据其亚细胞定位发挥多种功能：调节膜结合钙黏蛋白的周转率、调节细胞质中小 Rho GTPase 的激活、调节核转录。在过去的二十年中，人们对 p120ctn 的认识有了显著的增长，这部分是通过使用不同的动物模型实现的。至少在青蛙和哺乳动物中，p120ctn 对正常发育和内稳态是必不可少的。在这里，我们将讨论不同的 p120ctn 异构体对钙黏蛋白周转率以及对细胞质和核内信号转导的影响。我们还将详细阐述 p120ctn 亚家族的其他成员：ARVCF、p0071 和 δ-连环蛋白的结构和功能。最后，我们将概述 p120ctn 家族成员在病理过程中的各自作用，特别是在癌症中，因为 p120ctn 经常发生改变。
