Department of Pharmacology and Experimental Neuroscience, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, United States; Developmental Neuroscience, Munroe-Meyer Institute, Durham Research Center II, Room 3031, University of Nebraska Medical Center, 985960 Nebraska Medical Center, Omaha, NE 68198-5960, United States.
Developmental Neuroscience, Munroe-Meyer Institute, Durham Research Center II, Room 3031, University of Nebraska Medical Center, 985960 Nebraska Medical Center, Omaha, NE 68198-5960, United States.
Semin Cell Dev Biol. 2017 Sep;69:70-82. doi: 10.1016/j.semcdb.2017.05.027. Epub 2017 Jun 9.
The cadherin-catenin complex in central neurons is associated with a variety of cytosolic partners, collectively called catenins. The p120ctn members are a family of catenins that are distinct from the more ubiquitously expressed α- and β-catenins. It is becoming increasingly clear that the functional roles of the p120ctn family of catenins in central neurons extend well beyond their functional roles in non-neuronal cells in partnering with cadherin to regulate adhesion. In this review, we will provide an overview of the p120ctn family in neurons and their varied functional roles in central neurons. Finally, we will examine the emerging roles of this family of proteins in neurodevelopmental disorders.
在中枢神经元中，黏附蛋白-catenin 复合物与多种细胞溶质伴侣相关，统称为连环蛋白。p120ctn 成员是连环蛋白家族的一部分，与更为广泛表达的α-和β-连环蛋白不同。越来越明显的是，p120ctn 家族连环蛋白在中枢神经元中的功能作用远远超出了它们在与黏附蛋白结合以调节黏附方面在非神经元细胞中的功能作用。在这篇综述中，我们将概述神经元中的 p120ctn 家族及其在中枢神经元中的各种功能作用。最后，我们将研究这个蛋白家族在神经发育障碍中的新兴作用。
