Cancer Biology Laboratory, Department of Anatomy and Cell Biology, Medical Building, The University of Melbourne, Parkville, Australia.
Front Biosci (Landmark Ed). 2012 Jan 1;17(2):784-804. doi: 10.2741/3957.
In multicellular organisms, the processes of tissue and organ formation are governed by morphogenetic signaling pathways. The Wnt pathways regulate morphogenesis by controlling cell adhesion and migration; processes that when corrupted, lead to tumorgenesis. It is well known that the Wnt signaling pathways affect adhesion and migration via downstream effectors. Canonical Wnt signaling regulates cell adhesion by regulating the stability of beta-Catenin, a component of the adherens junction. Whereas, non-canonical signaling modulates cytoskeletal dynamics by regulating the activity of downstream effectors that function to organize the cytoskeleton. Recent studies have uncovered a multitude of points of crosstalk between the Wnt pathways and the mechanisms that control cellular architecture, from the level of receptors to the level of transcription. At the same time, cellular mechanisms that are responsible for the regulation of adhesion and migration also function to modulate the activity of several Wnt pathway components. Uncovering these points of crosstalk may lead to better understanding and treatment of the processes that can lead to tumorgenesis.
在多细胞生物中，组织和器官形成的过程受形态发生信号通路的控制。Wnt 途径通过控制细胞黏附和迁移来调节形态发生；当这些过程受到干扰时，就会导致肿瘤发生。众所周知，Wnt 信号通路通过下游效应物影响黏附和迁移。经典的 Wnt 信号通过调节黏着连接的组成部分β-连环蛋白的稳定性来调节细胞黏附。而非经典信号则通过调节细胞骨架动力学来调节下游效应物的活性，从而组织细胞骨架。最近的研究揭示了 Wnt 途径与控制细胞结构的机制之间存在多种相互作用，从受体水平到转录水平。与此同时，负责调节黏附和迁移的细胞机制也可以调节几种 Wnt 途径成分的活性。揭示这些相互作用点可能有助于更好地理解和治疗导致肿瘤发生的过程。
