Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.
Front Biosci (Landmark Ed). 2012 Jan 1;17(3):976-83. doi: 10.2741/3968.
In order to maintain chromosomal stability during cell division, eukaryotic cells have evolved a number of surveillance mechanisms termed checkpoints. These checkpoints monitor the completion of essential molecular and cellular processes of one stage before entering another. The spindle checkpoint watches the bi-orientation attachment of spindle microtubules to all condensed chromosomes before initiation of nuclear division during mitosis. Histones are subject to a number of post-translational modifications during the cell cycle, which may in turn modify or facilitate cell cycle progression. Recent studies suggest that mitotic proteins including Bub1 and Sgo1 that are involved in the spindle checkpoint also play a major role in the regulation of histone modifications and chromatin remodeling. This mini-review summarizes emerging information about the new role of spindle checkpoint proteins in chromatin remodeling.
为了在细胞分裂过程中维持染色体稳定性，真核细胞进化出了许多称为检查点的监控机制。这些检查点在进入下一个阶段之前，监控一个阶段的重要分子和细胞过程的完成情况。纺锤体检查点在有丝分裂过程中核分裂开始之前，观察纺锤体微管与所有浓缩染色体的双定向附着。组蛋白在细胞周期中受到许多翻译后修饰的影响，这反过来又可能改变或促进细胞周期进程。最近的研究表明，参与纺锤体检查点的有丝分裂蛋白，包括 Bub1 和 Sgo1，也在组蛋白修饰和染色质重塑的调控中发挥主要作用。这篇综述总结了纺锤体检查点蛋白在染色质重塑中发挥新作用的新信息。
