Speranza Lorenza, Franceschelli Sara, Riccioni Graziano, Di Nicola Marta, Ruggeri Benedetta, Gallina Sabina, Felaco Mario, Grilli Alfredo
Department of Human Movement Sciences ,University G. D'Annunzio, Chieti Italy.
Front Biosci (Elite Ed). 2012 Jan 1;4(4):1255-62. doi: 10.2741/e456.
Heart Failure (HF) is characterized by activation inflammatory mediators that contributes to the disease progression. Brain natriuretic peptide (BNP) plasma levels increase in HF with a prognostic significance. The aim of this study was to evaluate the expression and activity of inducible nitric oxide synthase (iNOS) in peripheral blood mononuclear cell (PBMC) extracted from patients and a possible linear correlation between iNOS and plasma levels of BNP in decompensated chronic HF (DCHF) patients. To establish the DCHF, thirty-five male patients were evaluated. All patients were venesected within 24 h of admission to exclude an inflammatory state through evaluation of c-reactive protein. Only twenty subjects showed symptoms of DCHF were included in the study. Other patients were included in the control group. In DCHF, left ventricular ejection fraction (LVEF) percent was reduced and systolic pulmonary artery pressure (PAPs) was increased. Furthermore, iNOS expression and BNP plasma levels were significantly higher in patients with DCHF as compared to controls group. These findings indicate that in DCHF patients, iNOS activity exhibits a significant linear correlation with plasmatic BNP level.
心力衰竭（HF）的特征是炎症介质激活，这会促进疾病进展。脑钠肽（BNP）血浆水平在HF中升高，具有预后意义。本研究的目的是评估从患者中提取的外周血单核细胞（PBMC）中诱导型一氧化氮合酶（iNOS）的表达和活性，以及失代偿性慢性心力衰竭（DCHF）患者中iNOS与BNP血浆水平之间可能的线性相关性。为了确定DCHF，对35名男性患者进行了评估。所有患者在入院后24小时内进行静脉采血，通过评估C反应蛋白来排除炎症状态。只有20名出现DCHF症状的受试者被纳入研究。其他患者被纳入对照组。在DCHF中，左心室射血分数（LVEF）百分比降低，收缩期肺动脉压（PAPs）升高。此外，与对照组相比，DCHF患者的iNOS表达和BNP血浆水平显著更高。这些发现表明，在DCHF患者中，iNOS活性与血浆BNP水平呈显著线性相关。
