Lund University, Department of Cardiology, Malmö University Hospital, Sweden.
Int J Cardiol. 2011 Jun 16;149(3):364-71. doi: 10.1016/j.ijcard.2010.02.018. Epub 2010 Mar 3.
We assessed gender differences in variables related to B-natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), peak oxygen consumption (peak-VO2), and LV mass (LVM), among patients recently hospitalized for suspected heart failure (HF).
Of 930 consecutive patients, 409 accepted follow-up after discharge, 221 of these had definite HF (90 women, mean age 74.5 [9.8]years). In 141 HF patients (61 women) with BNP data, women had lower BNP than men (43.9 [38.1] versus 76.3 [88.9]pmol/L, P=0.0193). LVEF (all HF patients) was higher in women (49.8 [13.4] versus 42.4 [13.9]%, P=0.0004). Peak-VO2 (147 HF patients, 48 women) was lower in women (13.9 [4.3] versus 16.3 [4.2]mL/kg/min, P=0.0093). LVM index (200 HF patients, 78 women) was lower in women (130.4 [46.5] versus 171.7 [57.6]g/m(2), P<0.0001). Among HF patients, variables independently related to BNP were body mass index (BMI) and peak-VO2 exclusively among men, mitral regurgitation, respiratory disease and angiotensin receptor blocker treatment only among women. Variables independently related to LVEF were resting heart rate, acetylic salicylic acid use and BNP exclusively among men. No variable was exclusive for women. Variables independently related to peak-VO2 were right ventricular size, BNP, resting and peak heart rate solely among men, BMI and stable angina pectoris exclusively among women. Variables independently related to LVM were left atrial diameter only among men, BMI exclusively among women.
Among elderly HF patients, there were some important gender differences in BNP, LVEF, peak-VO2 and LVM, and in variables independently related to these factors.
我们评估了最近因疑似心力衰竭（HF）住院的患者中与 B 型利钠肽（BNP）、左心室射血分数（LVEF）、峰值耗氧量（peak-VO2）和左心室质量（LVM）相关的变量的性别差异。
在 930 例连续患者中，409 例在出院后接受了随访，其中 221 例有明确的 HF（90 名女性，平均年龄 74.5[9.8]岁）。在 141 例有 BNP 数据的 HF 患者（61 名女性）中，女性的 BNP 低于男性（43.9[38.1]与 76.3[88.9]pmol/L，P=0.0193）。LVEF（所有 HF 患者）在女性中更高（49.8[13.4]与 42.4[13.9]%，P=0.0004）。peak-VO2（147 例 HF 患者，48 名女性）在女性中较低（13.9[4.3]与 16.3[4.2]mL/kg/min，P=0.0093）。LVM 指数（200 例 HF 患者，78 名女性）在女性中较低（130.4[46.5]与 171.7[57.6]g/m(2)，P<0.0001）。在 HF 患者中，与 BNP 独立相关的变量是体重指数（BMI）和 peak-VO2，仅在男性中，二尖瓣反流、呼吸系统疾病和血管紧张素受体阻滞剂治疗仅在女性中。与 LVEF 独立相关的变量是静息心率、乙酰水杨酸的使用和 BNP，仅在男性中。没有变量是女性独有的。与 peak-VO2 独立相关的变量是右心室大小、BNP、静息和峰值心率，仅在男性中，BMI 和稳定性心绞痛仅在女性中。与 LVM 独立相关的变量是左心房直径，仅在男性中，BMI 仅在女性中。
在老年 HF 患者中，BNP、LVEF、peak-VO2 和 LVM 以及与这些因素相关的变量之间存在一些重要的性别差异。
