Touz Maria C, Rivero Maria R, Miras Silvana L, Bonifacino Juan S
Instituto de Investigacion Medica Mercedes y Martin Ferreyra, INIMEC - CONICET, Friuli 2434, Cordoba, Argentina.
Front Biosci (Elite Ed). 2012 Jan 1;4(5):1898-909. doi: 10.2741/511.
Giardia is a flagellated protozoan parasite that has to face different microenvironments during its life cycle in order to survive. All cells exchange materials with the extracellular medium through the reciprocal processes of endocytosis and secretion. Unlike more evolved cells, Giardia lacks a defined endosomal/lysosomal system, but instead possesses peripheral vacuoles that play roles in endocytosis, degradation, recycling, and secretion of proteins during growth and differentiation of the parasite. This review focuses on recent reports defining the role of different molecules involved in protein trafficking to the peripheral vacuoles, and discusses possible mechanisms of receptor recycling. Since Giardia is an early-branching protist, the study of this parasite may lead to a clearer understanding of the minimal machinery required for protein transport in eukaryotic cells.
贾第虫是一种有鞭毛的原生动物寄生虫，在其生命周期中必须面对不同的微环境才能生存。所有细胞都通过内吞作用和分泌的相互过程与细胞外介质交换物质。与进化程度更高的细胞不同，贾第虫缺乏明确的内体/溶酶体系统，而是拥有外周液泡，这些外周液泡在寄生虫生长和分化过程中的蛋白质内吞、降解、循环利用和分泌中发挥作用。本综述重点关注最近关于确定参与蛋白质运输到外周液泡的不同分子作用的报告，并讨论受体循环利用的可能机制。由于贾第虫是一种早期分支的原生生物，对这种寄生虫的研究可能有助于更清楚地了解真核细胞中蛋白质运输所需的最小机制。
