• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

厌氧寄生原生动物中的内吞作用。

Endocytosis in anaerobic parasitic protists.

机构信息

Universidade Federal do Rio de Janeiro, Centro Nacional de Biologia Estrutural e Bioimagens, Rio de Janeiro, RJ, Brasil.

Universidade da Grande Rio, Duque de Caxias, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2024 Jul 26;119:e240058. doi: 10.1590/0074-02760240058. eCollection 2024.

DOI:10.1590/0074-02760240058
PMID:39082582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11285859/
Abstract

The incorporation of different molecules by eukaryotic cells occurs through endocytosis, which is critical to the cell's survival and ability to reproduce. Although this process has been studied in greater detail in mammalian and yeast cells, several groups working with pathogenic protists have made relevant contributions. This review analysed the most relevant data on the endocytic process in anaerobic protists (Entamoeba histolytica, Giardia intestinalis, Trichomonas vaginalis, and Tritrichomonas foetus). Many protozoa can exert endocytic activity across their entire surface and do so with great intensity, as with E. histolytica. The available data on the endocytic pathway and the participation of PI-3 kinase, Rab, and Rho molecular complexes is reviewed from a historical perspective.

摘要

真核细胞通过胞吞作用来摄取不同的分子，这对于细胞的生存和繁殖至关重要。虽然哺乳动物和酵母细胞中的胞吞作用已经得到了更深入的研究，但一些研究致病性原生动物的小组也做出了相关贡献。本综述分析了厌氧原生动物（溶组织内阿米巴、肠道贾第鞭毛虫、阴道毛滴虫和胎儿三毛滴虫）中胞吞作用的最相关数据。许多原生动物可以在整个表面上进行胞吞作用，并且强度很大，就像溶组织内阿米巴一样。本文从历史角度回顾了胞吞途径以及 PI-3 激酶、Rab 和 Rho 分子复合物的参与的相关数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/ca4316df3051/1678-8060-mioc-119-e240058-gf16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/9a786e3d0dbf/1678-8060-mioc-119-e240058-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/f5d4f7bf77f5/1678-8060-mioc-119-e240058-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/ce37089bbcfc/1678-8060-mioc-119-e240058-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/03ee55072145/1678-8060-mioc-119-e240058-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/c0aa21e83e08/1678-8060-mioc-119-e240058-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/335a9e91a168/1678-8060-mioc-119-e240058-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/bb29483b1ff7/1678-8060-mioc-119-e240058-gf7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/631aecb0f360/1678-8060-mioc-119-e240058-gf8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/4dd508593d11/1678-8060-mioc-119-e240058-gf9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d65d53d6e13f/1678-8060-mioc-119-e240058-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/adc115ee7e21/1678-8060-mioc-119-e240058-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d7bccd27be3a/1678-8060-mioc-119-e240058-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d8d0cff3072c/1678-8060-mioc-119-e240058-gf13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/528012b7623d/1678-8060-mioc-119-e240058-gf14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/3baa4d0661e9/1678-8060-mioc-119-e240058-gf15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/ca4316df3051/1678-8060-mioc-119-e240058-gf16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/9a786e3d0dbf/1678-8060-mioc-119-e240058-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/f5d4f7bf77f5/1678-8060-mioc-119-e240058-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/ce37089bbcfc/1678-8060-mioc-119-e240058-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/03ee55072145/1678-8060-mioc-119-e240058-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/c0aa21e83e08/1678-8060-mioc-119-e240058-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/335a9e91a168/1678-8060-mioc-119-e240058-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/bb29483b1ff7/1678-8060-mioc-119-e240058-gf7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/631aecb0f360/1678-8060-mioc-119-e240058-gf8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/4dd508593d11/1678-8060-mioc-119-e240058-gf9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d65d53d6e13f/1678-8060-mioc-119-e240058-gf10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/adc115ee7e21/1678-8060-mioc-119-e240058-gf11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d7bccd27be3a/1678-8060-mioc-119-e240058-gf12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/d8d0cff3072c/1678-8060-mioc-119-e240058-gf13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/528012b7623d/1678-8060-mioc-119-e240058-gf14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/3baa4d0661e9/1678-8060-mioc-119-e240058-gf15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4954/11285859/ca4316df3051/1678-8060-mioc-119-e240058-gf16.jpg

相似文献

1
Endocytosis in anaerobic parasitic protists.厌氧寄生原生动物中的内吞作用。
Mem Inst Oswaldo Cruz. 2024 Jul 26;119:e240058. doi: 10.1590/0074-02760240058. eCollection 2024.
2
Highly Potent 1-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites.高活性 1-1,2,3-三唑键合色酮-甲硝唑偶联物抗厌氧食源性、水源性和性传播原生动物寄生虫。
Front Cell Infect Microbiol. 2018 Oct 30;8:380. doi: 10.3389/fcimb.2018.00380. eCollection 2018.
3
Extracellular vesicles released by anaerobic protozoan parasites: Current situation.厌氧原生动物寄生虫释放的细胞外囊泡：现状。
Cell Microbiol. 2020 Nov;22(11):e13257. doi: 10.1111/cmi.13257. Epub 2020 Sep 10.
4
In vitro effect of nitazoxanide against Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis trophozoites.硝唑尼特对溶组织内阿米巴、肠贾第虫和阴道毛滴虫滋养体的体外作用。
J Eukaryot Microbiol. 2002 May-Jun;49(3):201-8. doi: 10.1111/j.1550-7408.2002.tb00523.x.
5
TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries.TriTOX：一种新型阴道毛滴虫检测平台，可用于化合物文库的高通量筛选。
Int J Parasitol Drugs Drug Resist. 2021 Apr;15:68-80. doi: 10.1016/j.ijpddr.2021.01.001. Epub 2021 Feb 10.
6
YI-S, a casein-free medium for axenic cultivation of Entamoeba histolytica, related Entamoeba, Giardia intestinalis and Trichomonas vaginalis.YI-S，一种用于无菌培养溶组织内阿米巴、相关阿米巴、肠贾第虫和阴道毛滴虫的无酪蛋白培养基。
J Eukaryot Microbiol. 1995 May-Jun;42(3):277-8. doi: 10.1111/j.1550-7408.1995.tb01579.x.
7
Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica.关于编码铁氧化还原蛋白、硝基还原酶、NADH氧化酶和乙醇脱氢酶3的基因从厌氧原核生物横向转移至蓝氏贾第鞭毛虫和溶组织内阿米巴的证据。
Eukaryot Cell. 2002 Apr;1(2):181-90. doi: 10.1128/EC.1.2.181-190.2002.
8
Glycogen phosphorylase sequences from the amitochondriate protists, Trichomonas vaginalis, Mastigamoeba balamuthi, Entamoeba histolytica and Giardia intestinalis.来自无线粒体原生生物阴道毛滴虫、巴氏鞭毛虫、溶组织内阿米巴和肠贾第虫的糖原磷酸化酶序列。
J Eukaryot Microbiol. 2003 Sep-Oct;50(5):366-72. doi: 10.1111/j.1550-7408.2003.tb00151.x.
9
Drug targets and mechanisms of resistance in the anaerobic protozoa.厌氧原生动物中的药物靶点与耐药机制
Clin Microbiol Rev. 2001 Jan;14(1):150-64. doi: 10.1128/CMR.14.1.150-164.2001.
10
Fibronectin- and laminin-mediated endocytic activity in the parasitic protozoa Trichomonas vaginalis and Tritrichomonas foetus.纤连蛋白和层粘连蛋白介导的阴道毛滴虫和胎儿三毛滴虫的内吞活性
J Submicrosc Cytol Pathol. 1990 Jan;22(1):39-45.

本文引用的文献

1
Complement receptor 3 is required for maximum in vitro trogocytic killing of the parasite Trichomonas vaginalis by human neutrophil-like cells.补体受体 3 对于人中性粒细胞样细胞体外最大程度地吞噬寄生虫阴道毛滴虫是必需的。
Parasite Immunol. 2024 Feb;46(2):e13025. doi: 10.1111/pim.13025.
2
Autophagy in protists and their hosts: When, how and why?原生生物及其宿主中的自噬：何时、如何以及为何发生？
Autophagy Rep. 2023;2(1). doi: 10.1080/27694127.2022.2149211. Epub 2023 Mar 9.
3
Macropinocytosis: mechanisms and regulation.巨胞饮作用：机制与调控。
Biochem J. 2023 Mar 15;480(5):335-362. doi: 10.1042/BCJ20210584.
4
Insights of Endocytosis Signaling in Health and Disease.内吞作用信号转导在健康和疾病中的研究进展。
Int J Mol Sci. 2023 Feb 3;24(3):2971. doi: 10.3390/ijms24032971.
5
Combined nanometric and phylogenetic analysis of unique endocytic compartments in Giardia lamblia sheds light on the evolution of endocytosis in Metamonada.纳米级和系统发生分析联合揭示了 Giardia lamblia 独特内吞小体的进化
BMC Biol. 2022 Sep 21;20(1):206. doi: 10.1186/s12915-022-01402-3.
6
PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica.PI 激酶-EhGEF2-EhRho5 轴促进脂多糖刺激的溶组织内阿米巴大胞饮作用。
PLoS Pathog. 2022 May 20;18(5):e1010550. doi: 10.1371/journal.ppat.1010550. eCollection 2022 May.
7
Assessment of country implementation of the WHO global health sector strategy on sexually transmitted infections (2016-2021).评估各国执行世界卫生组织性传播感染全球卫生部门战略（2016-2021 年）的情况。
PLoS One. 2022 May 4;17(5):e0263550. doi: 10.1371/journal.pone.0263550. eCollection 2022.
8
Entamoeba histolytica EHD1 Is Involved in Mitosome-Endosome Contact.溶组织内阿米巴 EHD1 参与线粒体-内体接触。
mBio. 2022 Apr 26;13(2):e0384921. doi: 10.1128/mbio.03849-21. Epub 2022 Apr 11.
9
Trogocytosis in Unicellular Eukaryotes.单细胞真核生物中的胞饮作用。
Cells. 2021 Nov 1;10(11):2975. doi: 10.3390/cells10112975.
10
An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1.一种非典型 EhGEF 通过 EhRho1 调节溶组织内阿米巴的吞噬作用。
PLoS Pathog. 2021 Nov 22;17(11):e1010030. doi: 10.1371/journal.ppat.1010030. eCollection 2021 Nov.