白杨素的神经保护作用。 （注：原文中apocynin一般指白杨素，但如果结合具体医学文献背景，可能有其他含义，这里按照字面直接翻译）
The neuroprotective effects of apocynin.
作者信息
Simonyi Agnes, Serfozo Peter, Lehmidi Tareq M, Cui Jiankun, Gu Zezong, Lubahn Dennis B, Sun Albert Y, Sun Grace Y
机构信息
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
出版信息
Front Biosci (Elite Ed). 2012 Jan 1;4(6):2183-93. doi: 10.2741/535.
Abstract
The recognition of health benefits of phytomedicines and herbal supplements lead to an increased interest to understand the cellular and molecular basis of their biological activities. Apocynin (4-hydroxy-3-methoxy-acetophenone) is a constituent of the Himalayan medicinal herb Picrorhiza kurroa which is regarded as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, a superoxide-producing enzyme. NADPH oxidase appears to be especially important in the modulation of redox-sensitive signaling pathways and also has been implicated in neuronal dysfunction and degeneration, and neuroinflammmation in diseases ranging from stroke, Alzheimer's and Parkinson's diseases to psychiatric disorders. In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies.
摘要
对植物药和草药补充剂健康益处的认识，引发了人们对了解其生物活性的细胞和分子基础的更大兴趣。载脂联素（4-羟基-3-甲氧基苯乙酮）是喜马拉雅药用植物胡黄连的一种成分，被认为是烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶的抑制剂，NADPH氧化酶是一种产生超氧化物的酶。NADPH氧化酶在调节氧化还原敏感信号通路中似乎尤为重要，并且还与神经元功能障碍和退化以及从中风、阿尔茨海默病和帕金森病到精神疾病等一系列疾病中的神经炎症有关。在这篇综述中，我们旨在概述目前关于载脂联素在预防和治疗神经退行性疾病中的神经保护作用的文献。特别关注体内研究。
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NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.NADPH 氧化酶（NOX）同工型被塞拉菌素以双重作用模式抑制。
Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x.
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Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury.脑缺血再灌注损伤后中断再灌注可减少 NADPH 氧化酶的激活。
Free Radic Biol Med. 2011 Jun 15;50(12):1780-6. doi: 10.1016/j.freeradbiomed.2011.03.028. Epub 2011 Mar 31.
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NADPH-oxidase activation and cognition in Alzheimer disease progression.NADPH 氧化酶激活与阿尔茨海默病进程中的认知功能
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Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase.山奈酚通过直接抑制 NADPH 氧化酶来减轻 4-羟壬烯醛诱导的 PC12 细胞凋亡。
J Pharmacol Exp Ther. 2011 Jun;337(3):747-54. doi: 10.1124/jpet.110.176925. Epub 2011 Mar 11.
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NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion.短暂性脑缺血再灌注后突触后密度中 NADPH 氧化酶介导的蛋白质氧化损伤。
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