Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza, Egypt.
Oxid Med Cell Longev. 2022 Aug 22;2022:8741787. doi: 10.1155/2022/8741787. eCollection 2022.
A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration's extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.
脊髓损伤 (SCI) 是指脊髓受损或损伤，导致运动和感觉功能完全或部分丧失。活性氧物种和抗氧化防御水平生成的失衡导致氧化应激 (OS) 和神经炎症。SCI 后，OS 和发生的炎症途径是交联失调途径的重要剧烈驱动因素。它强调了多靶点治疗在对抗 SCI 后果中的重要性。多酚是植物来源的次生代谢物，有望作为治疗 SCI 的替代治疗药物。次生代谢物在 SCI 早期阶段对神经炎症、神经元 OS 和外在轴突失调途径具有活性。实验和临床研究表明，酚类化合物作为重要的植物化学物质，在调节上游失调的 OS/炎症信号介质以及 SCI 后外在轴突再生途径方面可能具有重要意义。此外，多酚类化合物的组合可能是减轻 SCI 影响的一种方法。
