Urade Takeshi, Kido Masahiro, Fukumoto Takumi, Hori Yuichi, Kusunoki Nobuya, Tsuchida Shinobu, Takahashi Masanori, Tanaka Motofumi, Kuramitsu Kaori, Tsugawa Daisuke, Gon Hidetoshi, Chuma Masashi, Fukushima Kenji, Matsumoto Ippei, Ajiki Tetsuo, Terashima Kazuki, Demizu Yusuke, Murakami Masao, Ku Yonson
Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Kobe University.
Gan To Kagaku Ryoho. 2011 Nov;38(12):2065-7.
We report a case of multiple advanced hepatocellular carcinomas (HCC) with bilobar distribution treated by combination therapy of hepatectomy and particle therapy (carbon ion therapy). A 73-year-old man who had been pointed out hepatic tumors on abdominal CT was referred to our hospital in February 2010. Advanced HCCs; 8 cm Vp3 and 6 cm in the left lobe, 4 cm in the posterior segment, and 1 .5 cm in the S8 area, were detected by abdominal dynamic CT and EOB-MRI etc. Curative resection was not applied due to insufficiency of liver function and unfavorable anatomical tumor locations. Accordingly we have developed a novel combination therapy of hepatectomy and particle therapy. First we performed left lobectomy in March 2010, followed by administration of particle therapy to the posterior segment for local control in May. Then, transcatheter arterial chemoembolization was administered 4 times for residual tumors. The patient survives for 15 months after the initial therapy with good local control.
我们报告了一例通过肝切除术和粒子治疗（碳离子治疗）联合治疗的双叶分布多发性晚期肝细胞癌（HCC）病例。一名73岁男性，腹部CT检查发现肝脏肿瘤，于2010年2月转诊至我院。通过腹部动态CT和EOB-MRI等检查发现了晚期HCC；右叶有一个8cm的Vp3肿瘤和一个6cm的肿瘤，后段有一个4cm的肿瘤，S8区域有一个1.5cm的肿瘤。由于肝功能不全和肿瘤解剖位置不佳，未进行根治性切除。因此，我们开发了一种肝切除术和粒子治疗的新型联合治疗方法。首先，我们于2010年3月进行了左叶切除术，随后于5月对后段进行了粒子治疗以进行局部控制。然后，对残留肿瘤进行了4次经动脉化疗栓塞。患者在初始治疗后存活了15个月，局部控制良好。
