College of Social Work, Trinity Institute for the Addictions, Florida State University, University Center, Building C, Tallahassee, FL 32306-2570, USA.
Psychopharmacology (Berl). 2012 Jul;222(1):17-26. doi: 10.1007/s00213-011-2618-4. Epub 2011 Dec 28.
Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services.
Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices.
Alcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed.
Post-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse.
Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.
确定易变的神经认知预测因子对于酒精依赖个体的复发对于优化医疗保健的提供和临床服务非常重要。
鉴于酒精线索反应可以预测复发，我们评估了线索诱发的高频心率变异性（HFHRV）和酒精注意力偏差（AB）作为潜在的复发风险指标。
长期住院治疗的酒精依赖患者参加了正念导向治疗或成瘾支持小组，完成了空间线索任务，以衡量酒精 AB 和情绪调节的酒精线索反应性协议，同时评估了 HFHRV。
治疗后 HFHRV 线索反应性和酒精 AB 在 6 个月的随访中显著预测了复发的发生和时间，独立于治疗条件，并且在控制了酒精依赖严重程度之后也是如此。与未复发的患者相比，复发的酒精依赖患者对应激引发的酒精线索的 HFHRV 反应明显更大。
线索诱发的 HFHRV 和酒精 AB 可以预示复发，因此可能在临床环境中作为预后指标具有潜力。
