Querques Giuseppe, Bux Anna V, Iaculli Cristiana, Noci Nicola Delle
Department of Ophthalmology, Ospedali Riuniti, University of Foggia, Foggia, Italy.
Int Ophthalmol. 2011 Dec;31(6):525-7. doi: 10.1007/s10792-011-9493-1. Epub 2011 Dec 28.
To report on a patient who developed a lamellar macular hole 1 month after an intravitreal pegaptanib sodium injection. Interventional case report. A 66 year old patient developed a lamellar macular hole 1 month after an intravitreal pegaptanib sodium injection for diabetic macular edema (DME). The pathogenesis of the lamellar macular hole in our case can be attributed to the intravitreal injection that may have induced vitreous incarceration, causing vitreoretinal traction at the macula and development of a lamellar macular hole. Alternatively or in association, pegaptanib itself may have caused the lamellar macular hole by inducing sudden reduction of the DME and exacerbation of tangential traction of the posterior vitreous on the overlying macular retina. Lamellar macular hole seems to be a potential complication of pegaptanib injection even in patients without pretreatment clinically detectable vitreomacular traction.
报告1例玻璃体内注射培加他尼钠1个月后发生板层黄斑裂孔的患者。介入性病例报告。1例66岁患者因糖尿病性黄斑水肿（DME）接受玻璃体内注射培加他尼钠治疗，1个月后发生板层黄斑裂孔。本例板层黄斑裂孔的发病机制可能归因于玻璃体内注射，其可能导致玻璃体嵌顿，引起黄斑区玻璃体视网膜牵拉，进而形成板层黄斑裂孔。另外，培加他尼本身可能通过导致DME突然减轻以及加重后玻璃体对上方黄斑视网膜的切线方向牵拉而引起板层黄斑裂孔。即使在没有临床可检测到的玻璃体黄斑牵拉的患者中，板层黄斑裂孔似乎也是培加他尼注射的潜在并发症。
