Struckmann J R, Meiland H, Bagi P, Juul-Jørgensen B
Department of Urology/Vascular Surgery, Gentofte Hospital, University of Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 1990;69(3):209-15. doi: 10.3109/00016349009028682.
The venous muscle pump function was quantitatively assessed through pregnancy weeks 16, 30, 38 and 3 months (week 53) following delivery, in 24 pregnant women who completed a normal pregnancy. A statistically significant increase was found in the mean venous reflux (P less than 0.01), which was restored to initial values postpartum. Expelled calf volume remained stable throughout pregnancy but increased following delivery. Venous outflow from the legs was significantly reduced in the third trimester. Subjective symptoms of venous insufficiency increased through pregnancy, but, these symptoms had virtually disappeared post partum, corresponding to the muscle pump normalization. No statistical correlation was found between venous muscle pump values and changes in hormone concentrations of estradiol, estriol and progesterone. It is suggested that venous insufficiency development in pregnancy is caused primarily by mechanical obstruction, or hormonal influence other than that of estradiol, estriol or progesterone. 17% (4.7-37%) of the women with a normal pregnancy developed a pathological venous muscle pump function.
对24名正常妊娠的孕妇在妊娠第16周、30周、38周以及产后3个月（第53周）进行了静脉肌肉泵功能的定量评估。发现平均静脉反流有统计学意义的增加（P小于0.01），产后恢复到初始值。整个孕期小腿排出量保持稳定，但产后增加。妊娠晚期腿部静脉流出量显著减少。静脉功能不全的主观症状在孕期增加，但产后这些症状几乎消失，与肌肉泵功能正常化一致。未发现静脉肌肉泵值与雌二醇、雌三醇和孕酮激素浓度变化之间存在统计学相关性。提示孕期静脉功能不全的发生主要由机械性梗阻或除雌二醇、雌三醇或孕酮以外的激素影响所致。17%（4.7 - 37%）的正常妊娠女性出现了病理性静脉肌肉泵功能。
