Theravance, Inc, South San Francisco, California, USA.
Antimicrob Agents Chemother. 2012 Mar;56(3):1584-7. doi: 10.1128/AAC.05532-11. Epub 2011 Dec 27.
TD-1792 is a new multivalent glycopeptide-cephalosporin antibiotic with potent activity against Gram-positive bacteria. The in vitro activity of TD-1792 was tested against 527 Staphylococcus aureus isolates, including multidrug-resistant isolates. TD-1792 was highly active against methicillin-susceptible S. aureus (MIC(90), 0.015 μg/ml), methicillin-resistant S. aureus, and heterogeneous vancomycin-intermediate S. aureus (MIC(90), 0.03 μg/ml). Time-kill studies demonstrated the potent bactericidal activity of TD-1792 at concentrations of ≤ 0.12 μg/ml. A postantibiotic effect of >2 h was observed after exposure to TD-1792.
TD-1792 是一种新型的多价糖肽-头孢菌素抗生素，对革兰氏阳性菌具有强大的活性。TD-1792 的体外活性对 527 株金黄色葡萄球菌进行了测试，包括多药耐药株。TD-1792 对甲氧西林敏感的金黄色葡萄球菌（MIC90，0.015μg/ml）、耐甲氧西林金黄色葡萄球菌和异质性万古霉素中介金黄色葡萄球菌（MIC90，0.03μg/ml）具有高度活性。时间杀伤研究表明，TD-1792 在浓度≤0.12μg/ml 时具有强大的杀菌活性。在接触 TD-1792 后，观察到超过 2 小时的抗生素后效应。
